Adoptive Cell Therapy: CD4+ and CD8+ T Cells and the Cells that Educate Them

Nothando Swan


In adoptive cell therapy (ACT), patients’ own tumor-specific T cells are selected and expanded in vitro so that they can be re-administered with increased antitumor activity. Several studies have reported objective clinical responses in cancer patients who have received such autologous cell transfer. This review discusses the key differences in antigen recognition between CD4+ and CD8+ T cells. It then outlines the advances and clinical implementations of these cells in ACT as well as the utility of artificial antigen-presenting cells in tumor-specific T cell education and expansion.

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