A Review of Treatment Resistant Depression and Current Therapy Options

Alexander Ibrahim Mosa


There are no current first line therapies for Treatment Resistant Depression (TRD). Pharmacological and neuromodulatory therapies are used in the amelioration of depressive symptoms in treatment resistant patients, but no single treatment option has proven both effective and cost efficient. This review will outline current treatment approaches and discuss their relative efficacy. The viability of alternative treatments will be explored with a concluding focus on the potential of aerobic exercise therapy to replace current treatment options. This review is intended to influence the trajectory of research in finding clinically effective treatments, and suggest the potential of aerobic exercise in providing a cost effect, low relapse rate therapy for patients suffering from TRD.


Treatment Resistant Depression

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